Classification Results of Artificial Neural Networks for Alzheimer's Disease Detection

Detection of Alzheimer's disease on brain Magnetic Resonance Imaging (MRI) is a highly sought goal in the Neurosciences. We used four di erent models of Arti cial Neural Networks (ANN): Backpropagation (BP), Radial Basis Networks (RBF), Learning Vector Quantization Networks (LVQ) and Probabilistic Neural Networks (PNN) to perform classi cation of patients of mild Alzheimer's disease vs. control subjects. Features are extracted from the brain volume data using Voxelbased Morphometry (VBM) detection clusters. The voxel location detection clusters given by the VBM were applied to select the voxel values upon which the classi cation features were computed. We have evaluated feature vectors computed from the GM segmentation volumes using the VBM clusters as voxel selection masks. The study has been performed on MRI volumes of 98 females, after careful demographic selection from the Open Access Series of Imaging Studies (OASIS) database, which is a large number of subjects compared to current reported studies.